Table 2.

APIs and products approved in the USA for prevention of heartworm disease or treatment of heartworm infections.

Heartworm active API	Species	Route of application	Trade names	Combination product with	Company
Diethylcarbamazine citrate	dog, cat	oral	Carbam Diro-Form Dirocide/Filaribits/Pet-Dec Filban Nemacide		Bimeda AH Lloyd Zoetis Intervet Cronus Pharma
dog	oral	Filaribits Plus	Oxibendazole	Zoetis
Eprinomectin	cat	topical	Centragard	Praziquantel	Boehringer lngelheim AH
Ivermectin	dog, cat	oral	Heartgard generics thereof: Iverhart Ivermectin		Boehringer lngelheim AH Virbac AH Cronus Pharma
	dog	topical	Advantage DUO	Imidacloprid	Elanco
	dog	oral	Heartgard Plus generics thereof: Iverhart Plus Tri-Heart Plus	Pyrantel Pamoate	Boehringer lngelheim AH Virbac AH Heska
dog	oral	Panacur Plus	Praziquantel, Fenbendazole,	Intervet
dog	oral	Iverhart Max	Praziquantel, Pyrantel pamoate	Virbac AH
Milbemycin oxime	dog, cat	oral	Interceptor generic thereof: MilbeGuard		Elanco Ceva Sante Animale
	dog	oral	Sentinel	Lufenuron	Intervet
	dog	oral	Sentinel Spectrum	Lufenuron, Praziquantel	Intervet
dog	oral	Interceptor Plus	Praziquantel	Elanco
dog	oral	Trifexis	Spinosad	Elanco
Moxidectin	dog	oral s.c. topical	ProHeart Proheart 6/12 Coraxis		Zoetis Elanco
	dog, cat, ferret	topical	Advantage Multi generic thereof: Imoxi	Imidacloprid	Elanco Vetoquinol
cat	topical	Bravecto Plus	Fluralaner	Intervet
dog	oral	Simparica Trio	Sarolaner, Pyrantel pamoate	Zoetis
Selamectin	dog, cat	topical	Revolution generic therof: Revolt, Selarid, Senergy		Zoetis Aurora Pharmaceutical, Norbrook Laboratories, Chanelle Pharmaceuticals
cat	topical	Revolution Plus	Sarolaner	Zoetis
Arsenamide sodium	dog	i.v.	Caparsolate Sodium not marketed anymore		Boehringer lngelheim AH
Melarsomine dihydrochloride	dog	i.m.	Immiticide generic thereof: Diroban		Boehringer lngelheim AH Anzac AH

Preventives dominate the market; only three products are approved for adulticidal treatment (see last two rows of table). Data retrieved from: U.S. Food & Drug Administration https://animaldrugsatfda.fda.gov/adafda/views/#/search, accessed November 30th, 2020; AH – Animal Health.