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. 2021 May 28;12:3225. doi: 10.1038/s41467-021-23502-4

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© The Author(s) 2021, corrected publication 2021

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Fig. 7 — a Lugdunin BGC with the four ORFs shown in different colors. The squares represent the A-domains. b Assembly lines formed by duplication of a single NRPS subunit (corresponding to each ORF) zero, one, and two times are pictured. NRPminer explores all assembly lines generated by duplicating each ORF up to two times when the “OrfDup” option is selected. c The NRPS assembly lined (with A-, C-, PCP-, and E-domains pictured) appearing in the NRPS that synthesizes lugdunin, where one Val-specific A-domain loads three amino acids (valines) to the growing peptide. Amino acids corresponding to lugdunin structure are shown below each A-domain. Circles represent amino acids (different amino acids are shown by different colors). d Cyclic structure of lugdunin with the amino acids highlighted in blue. The “Cys*” represent Cys-derived thiazolidine in lugdunin structure.