Table 2.
Predicted amino acids for the eight A-domains appearing on cyclic surugamides A–D assembly line SurugamideAL.
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|---|---|---|---|---|---|---|
| Val (100) | Phe (100) | Tyr (100) | Val (100) | Ala (100) | Val (100) | Val (100) | Met (100) |
| Ile (80) | Tyr (90) | Phe (100) | Ile (100) | Ser (87) | Ile (100) | Ile (100) | Apa (100) |
| Abu (70) | Bht (90) | Leu (100) | Abu (70) | Pro (75) | Abu (70) | Abu (70) | Glu (86) |
| Val (75) | Arg (86) | ||||||
| Cys (75) | Gln (86) | ||||||
| Phe (75) | Lys (86) | ||||||
| Gly (75) | Asp (86) | ||||||
| Val (86) | |||||||
| Orn (86) |
Ai represents the set of amino acids predicted for the ith A-domain in . For each Ai at least three amino acids with the highest normalized specificity scores (listed in parentheses) are presented. Amino acids appearing in surugamide A (IFLIAIIK) are shown in bold. NRPminer considers all amino acids with the same normalized specificity score, as illustrated in the case of the fifth and the eighth A-domains.