Table 2.

Gabapentin and pregabalin pharmacokinetics and drug interactions

Pharmacokinetics and drug interactions	Gabapentin	Pregabalin
Half-life	5–7 h	6 h
Drug Interactions	Morphine increases concentrations Oral anatacids containing magnesium and aluminum hydroxide reduce bioavailability by 20%	No known drug interactions
Starting dosing	100 mg	75 mg
Timing for onset of action	Days	Weeks

Information in this table is taken from gabapentin and pregabalin US Food and Drug Adminisraton labels [28–31]