Table 3.
Social function outcomes in patients with alopecia areata
| AA study population | N | COA tool | Score (mean ± SD)a | References |
|---|---|---|---|---|
| Adults, children age ≥ 13 years with alopecia; most had AA (83%); 59% with AA had AT/AU; 97% were female | 338 | SPIN | 47.5% of patients with score ≥ 19 (clinically significant symptoms of social anxiety) | Montgomery et al. 2017 [25] |
| Adults, children age > 16 years: 32% with severe AA; 73% were female | 60 | SF-36 | Social functioning 70.8 ± 27.0 | Jankovic et al. 2016 [20] |
| Skindex-29 | Social functioning 22.0 ± 22.6 | |||
| Adults, age 18–60 years: 80% with < 50% hair loss; 52% were women | 50 | SF-36 | Social functioning 54.6 ± 33.8 (Controls: 82.2 ± 18.6; p < 0.001) | Masmoudi et al. 2013 [22] |
| Adults, age ≥ 18 years: 62% with < 50% hair loss; 62% were women | 37 | SF-36b | Social functioning 70.6 ± 26.6 (Controls: 86.5 ± 20.5; p < 0.001) | de Hollanda et al. 2014 [13] |
| Adults, age ≥ 18 years | 17 | Skindex-16 | Social functioning 33.1 ± 31.4 | Essa et al. 2018 [17] |
| Age and severity not reported; 100% were women | 23 | Skindex-16 | Functionb 52.2 ± 6.3 | Reid et al. 2012 [29] |
| Adults, age > 18 years: Severity and gender not reported | 11 | Skindex-29 | Function 16.7 ± 16.0 | Sanclemente et al. 2017 [32] |
| Adults, age 18–70 years: 33% with patchy AA, 14% ophiasis, 29% AT, 24% AU; 76% were women | 21 | Skindex-17 | Psychosocial subscale: 8.9 ± 6.7 (moderate impairment) | Willemsen et al. 2011 [39] |
| Adults, age 18–65 years: 96% with < 25% hair loss; none with AT/AU; 34% were women | 73 | SCL-90 | Phobic anxiety 0.4 ± 0.5 (Controls: 0.4 ± 0.6) | Annagur et al. 2013 [10] |
| Age > 12 years: 38% with < 50% hair loss; 62% with > 50% hair loss; 67% were women | 24 | SCL-90 | Phobic anxiety 2.8 ± 4.0 (Controls: 1.5 ± 2.7; Cohen’s d 0.37) | Talaei et al. 2017 [35] |
| Adults, age > 18 years: 12% with AT/AU; 50% were women | 168 | SCL-90 | Phobic anxiety 1.3 ± 0.4 (Controls: 1.1 ± 0.1; p < 0.05) | Tan et al. 2015 [36] |
| Adults, age > 18 years: 45% were women | 56 | Hairdex scale | Total 57.0 ± 27.0 | Gonul et al. 2018 [19] |
| Symptoms 6.7 ± 5.0 | ||||
| Functioning 4.0 ± 3.4 | ||||
| Emotions 24.4 ± 17.0 | ||||
| Confidence 17.4 ± 7.3 | ||||
| Stigmatization 4.7 ± 6.0 |
QoL Quality of life, SCL-90 Symptom Checklist 90,SF-36 Short Form 36, Skindex -16, 17, 29 16-, 17-, or 29-item Skindex, SPIN Social Phobia Inventory
aTotal possible scores: SPIN: 17 items; score ≥ 19 indicates symptoms of social anxiety; SF-36: Social functioning score range standardized to 0–100 (higher score = better QoL); Skindex-29 and Skindex-16: 0–100 (lower score = better QoL); Skindex-17: 0 (little impairment) to 24 (high impairment); SCL-90: 90 items, answered on 5-point scale, from 0 “none” to 4 “extremely”; Hairdex: 48 items, all hair-specific; assesses five categories: symptoms, functioning, emotions, confidence, and stigmatization. Patients score questions from 0 to 4 according to frequency of occurrence. Higher scores on all but confidence indicate a lower level of HRQoL
bMean ± standard error of the mean