In addition to itch and urticaria, dermatological applications of H-1 antihistamines include scarring and nonscarring alopecia, acne, Darier disease, eosinophilic dermatoses, paraneoplastic dermatoses, psoriasis, lichen nitidus, radiation dermatitis, skin dysesthesia, and cutaneous malignancies. However, most applications were documented in case reports, case series, or cohort studies; thus, further randomized controlled trials are warranted to evaluate their true efficacy.

Although evidence supporting the use of H-1 antihistamines for dermatologic purposes other than itch and urticaria control remains limited, more studies are encouraged, considering the relative low cost and safety of H-1 antihistamines.