Fig. 8.

Blockade of lysosomal TRPML1 channel-mediated Ca²⁺ release in podocytes by H₂O₂. A. A representative curve showing that ML-SA1 induced remarkable elevation of GCaMP3 signal in podocytes pre-treated with vehicle. B. A representative curve showing that ML-SA1 had no effects on GCaMP3 signal in podocytes pre-treated with H₂O₂. C. Summarized data showing GCaMP3 fluorescence in different groups of podocytes (n = 6–8). *p < 0.05 vs. Ctrl group, #p < 0.05 vs. Vehl group. Ctrl group. Ctrl, control; Vehl, vehicle; H₂O₂, hydrogen peroxide.