Table 3.
Factors associated with percent change in lumbar spine, femoral neck, total hip BMD and TBS over the first 48 weeks in the multivariable linear regression analysis (N = 233).
| Variable | Percent Change in Lumbar Spine BMD |
Percent Change in Femoral Neck BMD |
Percent Change in Total Hip BMD |
Percent Change in TBS |
||||
|---|---|---|---|---|---|---|---|---|
| β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | β (95% CI) | p | |
| Age (per 10-year increment) | −0.379 (−0.879, 0.121) | 0.136 | 0.008 (−0.499, 0.515) | 0.975 | −0.170 (−0.569, 0.230) | 0.403 | −0.472 (−1.207, 0.263) | 0.207 |
| BMI | 0.205 (0.045, 0.365) | 0.012 | 0.111 (−0.051, 0.274) | 0.177 | 0.060 (−0.067, 0.188) | 0.352 | 0.237 (−0.005, 0.478) | 0.045 |
| CD4 + T cell count | NA | NA | NA | NA | NA | NA | 0.005 (0.0005, 0.0104) | 0.032 |
| HIV viral load | −1.174 (−2.049, −0.298) | 0.009 | −1.716 (−2.605, −0.827) | <0.001 | −1.240 (−1.939, −0.541) | 0.001 | NA | NA |
| TDF exposure | −1.392 (−2.334, −0.451) | 0.004 | −1.096 (−2.052, −0.140) | 0.025 | −1.409 (−2.162, −0.657) | <0.001 | −0.516 (−1.984, 0.952) | 0.489 |
| LPV/r exposure | −0.635 (−1.753, 0.483) | 0.264 | −1.084 (−2.220, 0.051) | 0.061 | −1.367 (−2.260, −0.474) | 0.003 | −0.048 (−1.733, 1.677) | 0.956 |
Abbreviations: CI, confidence interval; NA, not applicable (denotes p ≥ 0.20 in the univariate analysis); BMD, bone mineral density; TBS, trabecular bone score; BMI, body mass index; TDF, tenofovir disoproxil fumarate; LPV/r, lopinavir/ritonavir.