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. 2021 Apr 24;296:100707. doi: 10.1016/j.jbc.2021.100707

Figure 7.

Figure 7

Depletion of CtIP or overexpression of miR-302b suppresses invasion and metastasis of colon cancer cells.A, Matrigel invasion assays were performed using the indicated cells. Left, representative micrographs for the CtIP-KO and wildtype cells. The scale bars represent 100 μm. Right, quantification of the numbers of invasive cells per field of view (FOV). Data represent mean ± SD. The p values are indicated as ∗∗p < 0.01. B, left, representative photographs and corresponding fluorescence images of orthotopic RFP colon colorectal cancer nude-mouse model autopsies of the control and CtIP-KO groups. Pink and blue arrows indicate primary and metastatic tumors, respectively. Right, fluorescence images of collected primary and metastatic tumors. The scale bars represent 1 cm. C, quantification of tumor weights (left) and frequency of metastases (right) in control and CtIP-KO groups. Data represent mean ± SD. The p values are indicated as ∗∗p < 0.01. D, quantification of tumor weights (left) and frequency of metastases (right) in control and miR-302b–overexpression groups. Data represent mean ± SD. The p values are indicated as ∗p < 0.05. CtIP, C-terminal-binding protein–interacting protein.