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. 2021 May 4;296:100749. doi: 10.1016/j.jbc.2021.100749

Figure 7.

Figure 7

Energy landscapeanalysisof the ryanodine receptor channel based on observation of single particles from cryo-EM. Energy landscapes from of the apo (closed) state (A, top) and ligand-bound (open) state (A, bottom). The curved path shows one probable path from the closed to open states. Shown in B is the probability map for the transition from closed to open states (79).