Table 3. Mean tumor growth time, delay time, inhibition rate and enhancement ratio in PC3 tumor-bearing mice after treatments with orlistat alone, castration alone and the combination of both.
| Treatment | MTGT (day)1 | MTGDT (day)2 | Mean growth inhibition rate3 | Enhancement ratio4 |
|---|---|---|---|---|
| Sham control | 13.1 | NA6 | NA6 | NA6 |
| Castration (Cast) | 22.5 | 9.40 | 1.72 | 2.45 |
| Orlistat (ORL) | 30.3 | 17.2 | 2.31 | 1.83 |
| Cast+ORL5 | 55.3 | 42.2 | 4.22 | - |
The number of mice in each group was four to five, and all the experiments were repeated at least twice.
1
Mean tumor growth time (MTGT): the time at which the tumor volume ratio reached to 5.
2
Mean tumor growth delay time (MTGDT): the mean tumor growth time of the treated group minus that of the sham control group.
3
Mean growth inhibition rate: the mean tumor growth time of treated group/the mean tumor growth time of the sham control group.
4
Enhancement ratio: the mean growth inhibition rate of ORL+Cast group/the mean growth inhibition rate of ORL or Cast group.
5
ORL+Cast: combination treatment of orlistat plus castration.
6
NA: not available.