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. 2021 May 27;41(5):BSR20204203. doi: 10.1042/BSR20204203

Table 4. Mean tumor growth inhibition rate and CI in PC3 tumor-bearing mice after treatments with orlistat alone, castration alone and the combination of both.

Treatment Mean growth inhibitory rate1 Expected growth inhibitory rate2 CI3
Sham control - - -
Cast 0.216* - -
ORL 0.459***$$ - -
Cast+ORL 0.724***$$$## 0.576 0.651 (synergism)
1

Mean growth inhibitory rate: 1 − (the 56th day’s mean tumor volume ratio of treated group/the 56th day’s mean tumor volume ratio of the sham control group).

2

Expected growth inhibitory rate: inhibition rates of ORL+Cast minus the multiplication of both ORL and Cast inhibition rates.

3

CI: (1 − mean growth inhibitory rate of Comb)/(1 − expected growth inhibitory rate).*P<0.05 and ***P<0.001, all treatments vs. sham control. $$P<0.01 and $$$P<0.001, orlistat and combination vs. castration. ##P<0.01, combination vs. orlistat.