Table 4. Mean tumor growth inhibition rate and CI in PC3 tumor-bearing mice after treatments with orlistat alone, castration alone and the combination of both.
| Treatment | Mean growth inhibitory rate1 | Expected growth inhibitory rate2 | CI3 |
|---|---|---|---|
| Sham control | - | - | - |
| Cast | 0.216* | - | - |
| ORL | 0.459***$$ | - | - |
| Cast+ORL | 0.724***$$$## | 0.576 | 0.651 (synergism) |
1
Mean growth inhibitory rate: 1 − (the 56th day’s mean tumor volume ratio of treated group/the 56th day’s mean tumor volume ratio of the sham control group).
2
Expected growth inhibitory rate: inhibition rates of ORL+Cast minus the multiplication of both ORL and Cast inhibition rates.
3
CI: (1 − mean growth inhibitory rate of Comb)/(1 − expected growth inhibitory rate).*P<0.05 and ***P<0.001, all treatments vs. sham control. $$P<0.01 and $$$P<0.001, orlistat and combination vs. castration. ##P<0.01, combination vs. orlistat.