Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 29;21:632. doi: 10.1186/s12885-021-08388-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — CRISPR screen reveals drug resistance genes. A Schematic describing our screening protocol. B A scatterplot shows the mean L2FC sum for all four drugs assayed in each of two cell lines compared to the log₁₀ p-value for the association of the same gene’s expression with with patient survival. ABCG2 stands out as the most highest L2FC over all four drugs. C Boxplots indicate the sgRNA fold change in counts per million comparing treated cells to control cells for each replicate and each cell line for the top ABCG2 sgRNA. Circles represent data from Panc-1 cells. Squares represent BXPC-3