Table 3.
Functional annotation clusters of the genes found in the global CNVR based on analysis in DAVID
| Cluster (Enrichment score, database) | Enrichment term | Gene count | p-value |
|---|---|---|---|
| 1 (1.89, KEGG_PATHWAY) | chx04020: Calcium signaling pathway | 31 | 0.001 |
| chx04970: Salivary secretion | 16 | 0.011 | |
| chx04022: cGMP-PKG signaling pathway | 25 | 0.016 | |
| chx04270: Vascular smooth muscle contraction | 19 | 0.037 | |
| chx04261: Adrenergic signaling in cardiomyocytes | 21 | 0.046 | |
| 2 (1.62, KEGG_PATHWAY) | chx04723: Retrograde endocannabinoid signaling | 24 | 0.000 |
| chx04724: Glutamatergic synapse | 24 | 0.000 | |
| chx04713: Circadian entrainment | 21 | 0.001 | |
| chx04728: Dopaminergic synapse | 25 | 0.002 | |
| chx04971: Gastric acid secretion | 16 | 0.004 | |
| chx04720: Long-term potentiation | 14 | 0.009 | |
| chx04970: Salivary secretion | 16 | 0.011 | |
| chx04925: Aldosterone synthesis and secretion | 15 | 0.014 | |
| chx04730: Long-term depression | 13 | 0.014 | |
| chx04540: Gap junction | 16 | 0.019 | |
| chx04750: Inflammatory mediator regulation of TRP channels | 18 | 0.020 | |
| chx04921: Oxytocin signaling pathway | 23 | 0.028 | |
| chx04922: Glucagon signaling pathway | 17 | 0.028 | |
| chx04972: Pancreatic secretion | 16 | 0.033 | |
| chx04270: Vascular smooth muscle contraction | 19 | 0.037 | |
| chx04725: Cholinergic synapse | 18 | 0.043 | |
| chx04911: Insulin secretion | 14 | 0.053 | |
| chx04726: Serotonergic synapse | 17 | 0.072 | |
| chx04915: Estrogen signaling pathway | 15 | 0.091 | |
| chx04961: Endocrine and other factor-regulated calcium reabsorption | 8 | 0.094 | |
| chx04912: GnRH signaling pathway | 13 | 0.131 | |
| chx04918: Thyroid hormone synthesis | 11 | 0.137 | |
| chx04924: Renin secretion | 10 | 0.161 | |
| chx04611: Platelet activation | 16 | 0.273 | |
| chx04916: Melanogenesis | 11 | 0.458 | |
| chx04310: Wnt signaling pathway | 14 | 0.599 | |
| 3 (1.14, KEGG_PATHWAY) | chx05204: Chemical carcinogenesis | 12 | 0.033 |
| chx00980: Metabolism of xenobiotics by cytochrome P450 | 10 | 0.075 | |
| chx00982: Drug metabolism - cytochrome P450 | 10 | 0.075 | |
| chx00830: Retinol metabolism | 9 | 0.152 |