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. 2021 May 29;20:80. doi: 10.1186/s12943-021-01374-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Correlations among p-JAK2, p-STAT5, and PD-L1 expression in ENKTL and PTCL tissues. a The representative immunohistochemical stainings of p-JAK2, p-STAT5, and PD-L1 in ENKTL tissues were shown. b Percent distribution of GM-CSF treatments for mature T-cell lymphoma. c Linear regression analysis of p-JAK2 and p-STAT5 immunohistochemical scores in ENKTL tissue microarray; P = 0.009, r = 0.416. d Linear regression analysis of p-STAT5 and PD-L1 immunohistochemical scores in ENKTL tissue microarray; P = 0.037, r = 0.398. e Immunohistochemical scores of p-JAK2 in patients with short-term progression after GM-CSF treatment or not. f Kaplan-Meier plots for progression-free survival analysis by the optimal cutoff value of p-JAK2 immunohistochemical scores. Samples were grouped as p-STAT5 high (H-score > 4.5), p-STAT5 low (H-score < 4.5). g Kaplan-Meier plots for overall survival analysis by the optimal cutoff value of PD-L1 immunohistochemical scores. Samples were grouped as PD-L1 high (H-score > 5.0), PD-L1 low (H-score < 5.0)