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. 2021 May 29;21:283. doi: 10.1186/s12935-021-01896-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Validation of the influence of CAFs abundance on BLCA progression in GEO cohort. a The correlation of TME cell types with ESTIMATE scores in the GEO cohort. High correlations between CAFs, stromal score (R = 0.89), immune score (R = 0.59) and ESTIMATE score (R = 0.80) were also observed. b Kaplan-Meier survival curves of high vs. low CAFs abundance in patients of GEO cohort. Patients in the high CAFs group presented a significantly lowered OS (p = 0.001). c The expression of each TME cell was shown after grouping by CAFs. Significant differences were found in stage, T and N classification between CAFs low and high abundance groups