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. 2021 May 29;21:283. doi: 10.1186/s12935-021-01896-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — CALD1 regulated the TME and promoted the progression of BLCA. a Kaplan-Meier curves of OS between high and low CALD1 group using Log-Rank test in TCGA BLCA cohort. ROC curve demonstrated the accuracy of CALD1 in predicting cancer progression, with an AUC of 0.679. The expression of CALD1 was significantly elevated with cancer progression. Three different bar plots showed the expression level of CALD1 in different tumor stages, T and N classification, respectively. b CAFs (p < 0.001), macrophages (p < 0.001), stromal score (p < 0.001), immune score (p < 0.001) and ESTIMATE score (p < 0.001) in the CALD1 high expression group were significantly higher than those in the CALD1 low expression group. c Close relationships of CALD1 with CAFs (R = 0.88, p < 0.001), Macrophages (R = 0.58, p < 0.001), stromal score (R = 0.84, p < 0.001), immune score (R = 0.51, p < 0.001) and ESTIMATE score (R = 0.72, p < 0.001) were observed in the TCGA cohort