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. 2021 May 29;21:283. doi: 10.1186/s12935-021-01896-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — CALD1 was significantly associated with a variety of TIICs and immune checkpoint related molecules. a The relative percentage of 22 kinds of TIICs calculated by the CIBERSORT algorithm was shown in the bar plot. b CALD1 was positively correlated with macrophages M0 (R = 0.18, p = 0.006), macrophages M2 (R = 0.30, p < 0.001), T cells CD4 memory resting (R = 0.27, p < 0.001), and negatively correlated with T cells CD8 (R=-0.31, p < 0.001). c The difference in infiltrated levels of TIICs between low and high CALD1 expression groups. d Higher expression levels of CTLA4 (p < 0.001), LAG3 (p < 0.001), PD-1 (p < 0.001), PD-L1 (p < 0.001), PD-L2 (p < 0.001), TIGIT (p < 0.001) and TIM3 (p < 0.001) were observed in the high CALD1 group compared with low CALD1group. eClose relationships between CALD1 and immune checkpoint-related genes in the TCGA cohort