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. 2021 May 24;14:2187–2206. doi: 10.2147/JIR.S291453

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© 2021 Mamun et al.

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Activating the caspase-1/4/5/8/11 signaling pathways, inflammatory factors including IL-1β and IL-18 release, and ROS generation, leading to GSDMD/GSDME-mediated pore formation as well as cell lysis and promote the development of diabetic complications.