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Response of MCF-7 cells to tamoxifen after long term tamoxifen exposure. MCF-7 cells were continuously cultured in phenol-red and FBS containing medium with 10−7 M tamoxifen. Characteristically, 5-day treatment of MCF-7 cells with tamoxifen (10−7 M) in the medium containing phenol red and 5% FBS causes 30% to 35% reduction in cell number. The inhibitory effect of TAM was gradually diminished in the cells continuously exposed to TAM over a period of 12 months (TAM-R).
