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. 2021 Feb 21;99(6):845–858. doi: 10.1007/s00109-021-02047-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — PLAC8 was associated with tamoxifen resistance in breast cancer patients. a Immunohistochemical analysis of PLAC8 expression in tamoxifen-resistant patients and tamoxifen-sensitive patients. b Immunohistochemical analysis of PLAC8 expression for primary tumor and their metastatic tumor from breast cancer patients. Scale bar represents 50μm. c The relationship between PLAC8 expression with tamoxifen resistance and sensitivity in primary breast cancer. PLAC8 expression was obtained for the intensity of PLAC8-positive staining (Low, 0-1; High 2-3). All data represent mean ± SD. **p < 0.01; *p < 0.05; NS, not significant