Table 2.

Non-telomeric roles of Pontin in cancer

Pontin	Cell/tissue type(s)	Functional outcome	Ref
Forms a complex with Polymerase I	Ovarian and liver cancer cell lines	Increased ribosomal RNA synthesis	[128]
Decondenses the chromatin	Xenopus embryos, Ovarian Cancer cell line	Increased cell proliferation	[131, 132]
Interacts with the mutant p53	Colorectal and Breast cancer	Increased tumor migration and invasion	[134]
Interacts with TIP60	Colon cancer cell lines	Regulates HIF1 dependent gene expression	[140]
Methylated Pontin recruit p300 to the promoters	Breast Cancer cell lines	Regulates expression of hypoxia genes	[143]