Table 3.

Non-telomeric roles of Reptin in cancer

Reptin	Cell/tissue Type(s)	Functional outcome	Ref
Controlling the chromatin structure	Breast cancer cell lines	Increased cyclin D1 expression and enhanced cell proliferation	[129]
Forms complex with β-catenin	Prostate cancer	Reduces expression of KAI1 tumor suppressor gene and increases cell growth	[130]
Decondenses the chromatin	Xenopus embryos, Ovarian cancer cell line	Increases cell proliferation	[131, 132]
Interacts with the wild-type p53	Non-small cell lung carcinoma and breast cancer cell lines	Inhibits expression of p53-dependent genes, increases cell proliferation and metastasis	[135–138]
Inhibits p14ARF	Non-small cell lung carcinoma and breast cancer cell lines	leads to activation of MDM2 and destabilization of p53 that causes enhanced proliferation	[138, 139]
Methylated Reptin recruits HDAC1 to the promoters	breast cancer cell lines	Regulates expression of hypoxia genes	[142]