Table 9.

Role of POT1 in different cancer types

Human malignancy	POT1 expression levels	Suggested functional outcome	Ref
Breast cancer	Downregulation of POT1 mRNA	Dysregulation of telomerase activity	[264]
Colorectal cancer	Upregulation of POT1 mRNA and protein		[170, 265]
Gastric cancer	Downregulation of POT1 mRNA in early cancer stage	Telomere dysfunction in early-stage cancer	[266]
	Downregulation of POT1; expression decreases with disease severity		[256]
Glioblastoma	Downregulation of POT1	Poorer prognosis	[267]
Hepatocellular carcinomas (HBV-related)	Upregulation of POT1 mRNA	Preserved 3′ overhang length, unlimited division of cancer cells, increased chromosomal instability	[175]
	Downregulation of POT1 mRNA and protein	Poorer prognosis	[180–182]
Splenic marginal zone lymphomas	Downregulation of POT1	Increased chromosomal instability	[268]
Melanoma	Upregulation of POT1		[269]
Familial papillary thyroid cancer	Downregulation of POT1 as compared to sporadic cancers		[240]