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. 2021 Apr 25;473(6):969–976. doi: 10.1007/s00424-021-02561-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Transforming growth factor-β type I receptor (TGF-βRI) is necessary for myostatin-induced Fgf23 gene expression. Arithmetic means ± SEM of relative (rel.) Fgf23 mRNA abundance in UMR106 osteoblast–like cells incubated without (white bars) or with (black bars) myostatin (100 ng/mL, 24 h, n = 7) in the presence or absence of TGF-βRI inhibitor SB431542 (10 µM, 24 h). **p < 0.01 indicates significant difference from control. #p < 0.05 indicates significant difference from the absence of SB431542 (2nd vs 4th bar). AU, arbitrary units (one-way ANOVA)