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. 2021 Feb 22;78(9):4335–4364. doi: 10.1007/s00018-021-03788-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Enhanced release and SV replenishment in Syt7 mutants. a Western analysis of Drosophila brain extracts separated on a 10–30% sucrose gradient. SYX1 labels the plasma membrane (left-most fraction) with SVs (n-SYB/SYT1) in intermediate fractions. SYT7 and SYT4 fractionate with other internal membrane compartments to distinct regions of the gradient. b Evoked release is increased in Syt7 null mutants (Syt7^M1) and Syt7 heterozygotes. c Optical mapping of release probability at larval NMJs demonstrate Syt7 mutant AZs are shifted to higher P_r compared to controls. d Syt7 mutants undergo rapid depression during a stimulation train and recover their releasable SV pool more quickly than controls. Heterozygotes show an intermediate phenotype. Panel a modified from [100] and panels b–d modified from [82]