Table 2.

Agonist-induced changes in I_sc in oral corpus caeci during ion replacement experiments

Oral corpus caeci	Propionate		Forskolin		Carbachol		n
	∆Isc (μEq·h−1·cm−2)
+ Cl−		3.39 ± 1.14		7.36 ± 0.89		1.76 ± 0.54	7
− Cl−	↓	0.25 ± 0.13*	↓	1.61 ± 0.89*	↓	0.11 ± 0.08*	7
+ Cl− (muc)		2.27 ± 0.71		9.63 ± 0.46		1.76 ± 0.38	6
− Cl− (muc)		4.52 ± 1.78	↓	4.85 ± 1.01*		3.19 ± 0.94	6
+ Cl− (ser)		8.03 ± 0.98		7.65 ± 1.04		4.14 ± 0.77	6
− Cl− (ser)	↓	0.60 ± 0.14*	↓	0.96 ± 0.27*	↓	0.80 ± 0.15*	6
+ HCO3−		4.01 ± 0.94		8.80 ± 0.49		4.74 ± 0.33	8
− HCO3−	↓	0.39 ± 0.18*	↓	4.24 ± 0.49*		3.53 ± 0.78	10
+ Na+ (ser)		6.38 ± 1.29		8.76 ± 0.71		3.93 ± 0.20	6
− Na+ (ser)	↓	0.95 ± 0.17*	↓	5.25 ± 0.24*	↓	0.72 ± 0.10*	6
+ Na+ (muc)		6.70 ± 0.80		8.53 ± 0.33		3.46 ± 0.32	6
− Na+ (muc)	↓	2.33 ± 0.97*		8.20 ± 0.40		2.60 ± 0.34	6

Increase in I_sc (∆I_sc) induced by propionate (2·10⁻³ mol·l⁻¹ at the mucosal side), forskolin (5·10⁻⁶ mol·l⁻¹ at the mucosal and the serosal side) and carbachol (5·10⁻⁵ mol·l⁻¹ at the serosal side) in the oral corpus caeci. Responses were tested in the presence and absence of Cl⁻, HCO₃⁻, or Na⁺ on the serosal (ser) and/or the mucosal (muc) side. Values are given as difference of the maximal change in I_sc induced by the agonist (peak) and the baseline just prior to administration of the drug and are means ± SEM

^*P < 0.05 versus response in the presence of the respective ion