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. 2021 May 29;7:125. doi: 10.1038/s41420-021-00504-1

Fig. 5. Avasimibe suppressed tumor growth but enhances CPT1A expression in DEN-injected mice on HFD.

Fig. 5

A Protocol for AVA in DEN-injected mice fed a high-fat diet. The mice were randomly assigned to NT, NT + HFD, HFD, and HFD + AVA group, and each group had 12 mice. B–C Avasimibe dramatically suppressed HFD-promoted HCC tumor growth. Representative images of the livers (B) and tumor volumes (C) from each group of mice were shown; **p < 0.01. D Representative H&E-stained images of HCC and adjacent non-tumor tissues from HFD or HFD + AVA group (n = 5, scale bar: 50 μm). T: tumor; NT: adjacent non-tumor. The circled position indicated no steatohepatitis area. E Representative IHC images of CyclinD1, TIP47, CPT1A, and HMGCL in tumor tissues from HFD-fed mice treated with or without AVA. Data were quantified using ImageJ software (means ± SEM, n = 5); *p < 0.05, **p < 0.01.