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. 2021 May 29;11:334. doi: 10.1038/s41398-021-01450-3

Fig. 2. Effect of oral minocycline treatment on translocator protein total distribution volume in participants with treatment-resistant major depressive disorder.

Fig. 2

There were no significant differences in prefrontal cortex, anterior cingulate cortex, or insula TSPO VT between pre- and post-minocycline treatment in the group receiving minocycline as compared to the group receiving placebo (repeated measures ANOVA, effect of group interaction, PFC: F1,19 = 0.28, P = 0.60; ACC: F1,19 = 0.54, P = 0.47; insula F1,19 = 1.6, P = 0.22). All second-generation TSPO radioligands, such as [18F]FEPPA, show differential binding according to the single-nucleotide polymorphism rs6971 of the TSPO gene, resulting in high-affinity binders (circles) and mixed-affinity binders (triangles). TSPO VT values represent raw values unadjusted for genotype. ANOVA analysis of variance, HAB high-affinity binder, MAB mixed-affinity binder, TSPO VT translocator protein total distribution volume, [18F]FEPPA, F 18-labeled N-(2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide).