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. 2021 May 29;12(6):558. doi: 10.1038/s41419-021-03828-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Number of nodules in peritoneal organs of Empty Vector or MDM4-SK-OV-3-injected mice (n = 6, two-tailed Student’s t test, p = 0.018). b Number of peritoneum membranes nodules as in c (n = 6, two-tailed Student’s t test, p = 0.0016). c Total number of nodules present in both peritoneal organs and peritoneum membranes (n = 6, two-tailed Student’s t test, p = 0.0016). d Percentage of mice showing ascites at the final time point (n = 6, χ² test, p < 0.0001). e Total number of nodules in Empty Vector or Mdm4-ID8 cells (n = 6 for Empty Vector, n = 7 for Mdm4, two-tailed Student’s t test, p = 0.0042). Nodules were counted blindly by two independent observers. f ID8 ascites analysis as in d (n = 15, χ² test p < 0.0001). g OS in mice injected with Empty Vector or MDM4-SK-OV-3 cells (n = 5, log-rank test, p < 0.001). h Correlation of MDM4 expression with OS in 1656 patients with epithelial ovarian cancer followed for 15 years (log-rank test, p = 0.0004).