Table 2.
Results of the mixed model analyses for IQ, hippocampal volume, cortical volume and CT in deletion carriers without medications compared to deletion carriers treated with SSRIs.
| Group effect | Interaction with age | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Model order | p-value | Log likelihood, df | Intercept NoMed | Intercept SSRIs | p-value | Log likelihood, df | Age Slope NoMed | Age Slope SSRIs | |
| WAIS/WISC | |||||||||
| FSIQ | Linear | <0.001 | 26.7, 2 | 78.5 ± 2.6 | 56.9 ± 3 | <0.001 | 16.56, 1 | −0.32 ± 0.13 | 0.55 ± 0.15 |
| VIQ | Linear | <0.001 | 16.18, 2 | 88.6 ± 3.2 | 69.1 ± 3.8 | <0.001 | 14.17, 1 | −0.75 ± 0.14 | 0.14 ± 0.16 |
| PIQ | Linear | <0.001 | 20.17, 2 | 74.2 ± 2.9 | 52.6 ± 3.6 | <0.001 | 12.80, 1 | −0.05 ± 0.39 | 0.82 ± 0.17 |
| Vocabulary | Linear | 0.013 | 8.58, 2 | 7.4 ± 0.9 | 3.6 ± 1 | 0.032 | 4.31, 1 | −0.07 ± 0.05 | 0.09 ± 0.54 |
| Hippocampal volume | |||||||||
| Dentate gyrus right | Quadratic | 0.028 | 9.51, 3 | 312.8 ± 28.4 | 295.6 ± 25.3 | 0.046 | 7.46, 2 | −0.28 ± 0.7 | −0.01 ± 0.04 |
| CA3 right | Quadratic | 0.019 | 6.89, 3 | 218.4 ± 27.7 | 232.3 ± 24.2 | 0.038 | 5.36, 2 | −0.16 ± 0.9 | 0.04 ± 0.06 |
| Cortical thickness | |||||||||
| Rostral middle frontal left | Linear | 0.030 | 9.8, 2 | 3.4 ± 0.06 | 3.2 ± 0.07 | 0.027 | 8.30, 1 | −0.02 ± 0.003 | −0.002 ± 0.003 |
| Rostral middle frontal right | Linear | 0.002 | 12.56, 2 | 3.3 ± 0.07 | 2.9 ± 0.08 | 0.004 | 9.66, 1 | −0.03 ± 0.004 | −0.001 ± 0.004 |
| Caudal middle frontal left | Linear | 0.030 | 7.96, 2 | 3.3 ± 0.06 | 3.1 ± 0.1 | 0.020 | 6.80, 1 | −0.03 ± 0.003 | −0.001 ± 0.003 |
| Caudal middle frontal right | Linear | 0.009 | 12.12, 2 | 3.3 ± 0.07 | 3.0 ± 0.01 | <0.001 | 8.82, 1 | −0.03 ± 0.004 | −0.001 ± 0.002 |
| Superior frontal left | Linear | 0.035 | 6.66, 2 | 3.7 ± 0.06 | 3.5 ± 0.07 | 0.045 | 6.39, 1 | −0.04 ± 0.003 | −0.015 ± 0.003 |
| Superior frontal right | Linear | 0.034 | 6.69, 2 | 3.6 ± 0.07 | 3.4 ± 0.07 | 0.020 | 7.20, 1 | −0.30 ± 0.004 | −0.012 ± 0.004 |
| Medial orbitofrontal left | Linear | 0.048 | 4.90, 2 | 3.5 ± 0.09 | 3.2 ± 0.09 | 0.021 | 4.82, 1 | −0.04 ± 0.005 | −0.02 ± 0.005 |
| Pars opercularis left | Linear | 0.034 | 11.00, 2 | 3.4 ± 0.05 | 3.1 ± 0.06 | 0.020 | 9.87, 1 | −0.02 ± 0.002 | −0.013 ± 0.003 |
| Pars triangularis right | Linear | 0.080 | 7.70, 2 | 3.4 ± 0.07 | 3.1 ± 0.08 | 0.034 | 7.66, 1 | −0.03 ± 0.004 | −0.01 ± 0.004 |
| Lateral orbitofrontal right | Linear | 0.040 | 9.78, 2 | 3.4 ± 0.07 | 3.2 ± 0.09 | 0.021 | 8.91, 1 | −0.03 ± 0.004 | −0.009 ± 0.001 |
| Superior temporal sulcus left | Linear | 0.011 | 12.98, 2 | 3.4 ± 0.06 | 3.1 ± 0.01 | 0.021 | 6.81, 1 | −0.02 ± 0.003 | −0.01 ± 0.003 |
P-values and log-likelihood values with degrees of freedom (df) are provided for the group and the group × age interaction effects. Additionally, β-values for the intercept and the age slope are listed for each group Values for CT are given in mm. All the p-values reported are FDR corrected.