Figure 4.

Probabilistic sensitivity analyses were conducted varying the toxicity rates, pain and depression efficacy of duloxetine, the sensitivity of the PHQ-9, and prevalence of depressive symptoms. 500 iterations of probabilistic inputs were run. Incremental cost-effectiveness ratios (ICERs) were calculated for each iteration comparing UC (grey dashed line), the depression screening strategy (blue), and universal duloxetine (green). The ICERs for these strategies were compared to a range of willingness-to-pay (WTP) thresholds, and that which produced the greatest quality-adjusted life expectancy while remaining below the WTP threshold was termed the preferred strategy. The probability of being the preferred strategy is plotted against various WTP thresholds.