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. 2021 May 25;14:2239–2252. doi: 10.2147/JIR.S310687

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© 2021 Zhou et al.

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Pharmacokinetics of MTX was evaluated using Tocilizumab and S3I-201 in NOD/SCID mice, followed by assessment using HPLC-MS/MS. (A) Clearance of MTX in ALL mice treated with TCZ. (B) Clearance of MTX in ALL mice treated with S3I-201. (C) AUC of MTX in ALL mice treated with TCZ. (D) AUC of MTX in ALL mice treated with S3I-201.