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. 2021 May 29;19:159. doi: 10.1186/s12951-021-00896-3

Fig. 30.

Fig. 30

Comparison of paclitaxel entry into endothelial cells in three formulations of Taxol and Abraxane and Abraxane containing methyl beta-cyclodextrin: Abraxane increases the cellular uptake of paclitaxel by 4.4 times compared to Taxol. When cyclodextrin is used as an inhibitor of 60 gp glycoprotein (which, by binding to albumin, causes endocytosis and increases its cellular uptake), the rate of drug uptake is very similar to that of Taxol, indicating a direct role for albumin in increasing paclitaxel cellular uptake [228, 229]