8. Comparison 10. Antimicrobial coolant compared to control coolant for preventing infectious diseases.
| Antimicrobial coolant compared to control coolant for preventing infectious diseases | ||||||
| Population: people undergoing aerosol generating procedures Setting: closed operatory Intervention antimicrobial coolant Comparison: control coolant | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | Number of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with control coolant | Risk with antimicrobial coolant | |||||
| Rate of infection of dental staff or patients | Not reported | |||||
| Reduction in volume of contaminated aerosols in the operative environment | Not reported | |||||
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Reduction in level of contamination in aerosols when chlorhexidine coolant was compared to distilled water during ultrasonic scaling at right side of patient |
The mean CFU level was 165.30 | MD 124 CFU lower (135.78 lower to 112.22 lower) | ‐ | 20 (1 RCT)a | ⊕⊝⊝⊝ VERY LOW 1 | |
|
Reduction in level of contamination in aerosols when povidone iodine coolant was compared to distilled water during ultrasonic scaling at side of patient |
The mean CFU level was 1064.05 | MD 656.45 CFU lower (672.74 lower to 640.16 lower) | ‐ | 40 (1 RCT)b | ⊕⊝⊝⊝ VERY LOW 1 | |
|
Reduction in level of contamination in aerosols when cinnamon coolant was compared to distilled water during ultrasonic scaling at right side of patient |
The mean CFU level was 1064.05 | MD 644.55 CFU lower (668.70 lower to 620.40 lower) | ‐ | 40 (1 RCT)b | ⊕⊝⊝⊝ VERY LOW 1 | |
| *The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CFU: colony‐forming units; CI: confidence interval; MD: mean difference; RCT: randomized controlled trial | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: we are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: we have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1. Downgraded 1 level for unclear risk of selection bias and reporting bias and 2 levels for imprecision due to small sample size reported in a single study