9. Comparison 11. Antimicrobial coolant A compared to antimicrobial coolant B for preventing infectious diseases.
| Antimicrobial coolant A compared to antimicrobial coolant B for preventing infectious diseases | ||||||
| Population: people undergoing aerosol generating procedures Setting: closed operatory Intervention: antimicrobial coolant A Comparison: antimicrobial coolant B | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | Number of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with antimicrobial coolant B | Risk with antimicrobial coolant A | |||||
| Rate of infection of dental staff or patients | Not reported | |||||
| Reduction in volume of contaminated aerosols | Not reported | |||||
|
Reduction in level of contamination in aerosols when chlorhexidine coolant was compared to cinnamon coolant during ultrasonic scaling at right side of patient |
The mean CFU level was 419.50 | MD 11.90 CFU lower (35.88 lower to 12.08 higher) | ‐ | 40 (1 RCT)a | ⊕⊝⊝⊝ VERY LOW 1 | |
|
Reduction in level of contamination in aerosols when chlorhexidine coolant was compared to povidone iodine coolant during ultrasonic scaling at right side of patient |
The mean CFU level was 100.60 | was MD 59.30 CFU lower (64.16 lower to 54.44 lower) | ‐ | 20 (1 RCT)b | ⊕⊝⊝⊝ VERY LOW 2 | |
| *The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CFU: colony forming units; CI: confidence interval; MD: mean difference; RCT: randomized controlled trial | ||||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1. Downgraded 1 level for unclear risk of detection and reporting bias, and 2 levels for imprecision due to small sample size reported in a single study
2. Downgraded 1 level for unclear risk of selection and reporting bias, and 2 levels for imprecision due to small sample size reported in a single study