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. 2021 May 12;8(6):1279–1291. doi: 10.1002/acn3.51365

Figure 2.

Figure 2

Gene expression profiling of GMLs from progressive MS brain. (A) Heatmap showing DEGs of NAGM and GML tissues from progressive MS brain (n = 8). (B) IPA analysis of GML DEGs (p < 0.05) showing enriched canonical pathway based upon z‐scores (orange—positive; purple—negative). (C) Representative heatmap image showing KEGG pathways associated with significantly dysregulated GML DEGs from progressive MS brains. (D–F) IHC images showing PLP, COL5A2, and RDX immunostaining in a demyelinated GML and surrounding NAGM from a progressive MS brain tissue. Scale bar—100 µm.