Table 3.
Modules altered by PRT in pwMS with primary metabolites included in the modules
| Module | Metabolites | p value | FDR adjusted p value |
|---|---|---|---|
| Black (Acylcarnitine metabolism) | Laurylcarnitine | 0.018 | 0.10 |
| 5‐dodecenoylcarnitine | |||
| Myristoleoylcarnitine | |||
| Decanoylcarnitine | |||
| Octanoylcarnitine | |||
| Hexanoylcarnitine | |||
| 3‐hydroxydecanoylcarnitine | |||
| Nonanoylcarnitine | |||
| 3‐hydroxyoleoylcarnitine | |||
| Pink (Fatty acid metabolism) | 3‐hydroxysebacate | 0.013 | 0.11 |
| Dodecanedioate | |||
| Tetradecanedioate | |||
| Hexanoylglutamine | |||
| 3‐hydroxyoctanoate | |||
| 3‐hydroxyhexanoate | |||
| Yellow (Fatty acid metabolism) | Palmitate | 0.0076 | 0.13 |
| 10‐nonadecenoate | |||
| Dihomolinoleate | |||
| Myristate | |||
| Linoleate | |||
| Oleate | |||
| Margarate | |||
| Docosapentaenoate (DPA) | |||
| Brown (Steroid metabolism) | Dehydroepiandrosterone sulfate (DHEAS) | 0.03 | 0.13 |
| Androstenediol‐3beta,17beta‐monosulfate | |||
| Pregnenetriol sulfate | |||
| Pregnenediol sulfate | |||
| Pregnenetriol disulfate | |||
| Androstenediol‐3alpha,17alpha‐monosulfate | |||
| Androstenediol‐3beta,17beta‐disulfate | |||
| Tan (Ether lipid metabolism) | 1,1‐enyl palmitoyl GPE | 0.03 | 0.13 |
| 1,1‐enyl stearoyl GPE | |||
| 1,1‐enyl oleoyl GPE | |||
| 1,1‐enyl stearoyl‐2‐arachidonoyl GPE | |||
| 1,1‐enyl stearoyl‐2‐oleoyl GPE | |||
| 1,1‐enyl palmitoyl‐2‐linoleoyl GPE | |||
| 1,1‐enyl stearoyl‐2‐linoleoyl GPE | |||
| Salmon (Phospholipid metabolism) | 1‐stearoyl GP | 0.03 | 0.13 |
| Oleoylcholine | |||
| Palmitoylcholine | |||
| Linoleoylcholine | |||
| 1‐palmitoyl GPI | |||
| Arachidonoylcholine |