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. 2021 May 4;8(6):1330–1342. doi: 10.1002/acn3.51371

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© 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Immunofluorescence staining reveals the distribution of intranuclear inclusions in both muscle fibers and nerve cells. (A) NOTCH2NLC protein partially co‐localized with p62‐positive intranuclear inclusions (marked with arrows and shown at a higher magnification) and p62‐positive inclusions in the rimmed vacuole (marked with arrow heads and shown at a higher magnification) in muscle fibers. (B) NOTCH2NLC protein partially co‐localized with p62‐positive intranuclear inclusions in nerve cells (marked with arrows and shown at a higher magnification). Nuclei were counterstained with DAPI. Scale bars = 25 μm.