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. 2021 May 30;10(6):e1280. doi: 10.1002/cti2.1280

Figure 6.

Figure 6

Functional defects and biased production of Th cytokines in mice with OVA‐induced lung inflammation receiving JQ1. (a) After repeated i.p. and i.t. OVA administration triggering allergic asthma and compared with those simply receiving OVA only, mice receiving daily steroids (but not those receiving JQ1) showed significantly lower airway resistance (a, left), and lower lung eosinophil peroxidase activity (a, right). (b) Mice immunised and administered daily with steroids, displayed lower levels of IL‐4 and IL‐5 in bronchoalveolar fluid (BALF) and (c) lower levels of IL‐4 and IL‐5 in lungs, while JQ1 had opposite effects. BUD: budesonide. Values are means ± SEM. Data are from 1 out of 2 in vivo experiments; groups include eight mice per condition tested. NS: not significant. *P < 0.05, **P < 0.01, ***P < 0.001 using the non‐parametric Kruskal–Wallis test followed by Dunn's multiple comparison test.