Table 3.
Outcomes of overall cohort and groups by development of SFGR
| All discordant MCDA twins (n = 70) | By development of SFGRa | |||
|---|---|---|---|---|
| SFGR present (n = 19) | SFGR absent (n = 15) | p-Value | ||
| Pregnancy outcomeb | ||||
| Good (dual delivery ≥ 30.0 wk) | 53 (73%) | 17 (89%) | 10 (67%) | 0.10 |
| Mixed (single loss or delivery 26.0–29.9 wk) | 17 (23%) | 2 (11%) | 5 (33%) | |
| Poor (dual loss or delivery < 26.0 wk) | 3 (4%) | 0 | 0 | |
| GA at delivery, wk | 33 (30.4–35.0) | 34 (32.3–35.3) | 32 (27.6–34.9) | 0.19 |
| BW discordance, % | 28 (20.1–35.1) | 29 (22.2–43.8) | 23 (13.4–30.2) | 0.12 |
| Latency from ITWD to delivery, d | 81 (60–102) | 88 (67–109) | 78 (47–101) | 0.18 |
| Latency from SFGR to deliveryc, d | 38 (7–65) | - | - | - |
| Latency from AREDF to deliveryd, d | 51 (40–78) | - | - | - |
Abbreviations: AREDF, absent or reversed end-diastolic flow; BW, birth weight; GA, gestational age; ITWD, intertwin weight discordance; MCDA, monochorionic, diamniotic; SFGR, selective fetal growth restriction.
Note: Continuous variables presented as median (interquartile range) and categorical variables as n (%).
n = 34 for this analysis due to inclusion of only those with adequate UCSF ultrasound follow-up to assess for development of SFGR (defined as last UCSF ultrasound within 4 weeks of delivery).
For this primary outcome, all n = 73 discordant MCDA twins were included. The remaining outcomes included n = 70, excluding the 3 who opted for termination of pregnancy following spontaneous intrauterine fetal demise of one twin.
Latency among the n = 19 who developed SFGR.
Latency among the n = 32 who developed AREDF