Figure 2.
Nasal fluid cytokine levels. Nasal fluid cytokine levels in controls and in children with asthma during well surveillance periods and RV-positive sick periods. RNA was tested for the virus using the Novaplex II RV16 Detection kit (Seegene, Walnut Creek, California). Cytokines were measured using Meso Scale Diagnostics multiplex biomarker assay kits and Meso Sector S600 reader (Rockville, Maryland) or Research and Development Luminex multiplex assays. Medians and interquartile range are illustrated. The asterisk indicates P <.05, Wilcoxon’s matched-pairs signed-rank test (for paired comparisons between well and RV samples), Mann-Whitney U test (for comparisons between controls and patients with asthma) or χ2 Wilcoxon rank-sum test (for IL-13). One-way nonparametric analysis of variance (Kruskal-Wallis test) followed by the 2-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli to correct for multiple comparisons. IFN, interferon; IL, interleukin; TNF, tumor necrosis factor; TSLP, thymic stromal lymphopoietin.