Table 1.
List of Treatment Exposures Included in Multivariable Models for Each Health Condition
| Health Conditiona | Condition-Specific Treatment Exposuresc |
|---|---|
| Cardiac | chest radiation, anthracyclines, alkylating agents (heavy metal, classic) |
| Pulmonary | chest radiation, bleomycin, alkylating agents (classic) |
| Endocrineb | Cranial and neck radiation, corticosteroids, methotrexate |
| Renal | abdominal radiation, ifosfamide, alkylating agents (heavy metal) |
| Neurology | cranial radiation, high dose intravenous methotrexate, intrathecal methotrexate/cytarabine |
| Gastrointestinal/Hepatic | neck, chest, and abdominal radiation |
| Musculoskeletal | cranial, chest, and abdominal radiation, methotrexate, corticosteroids, |
| Anxiety/Depression | cranial radiation, intrathecal methotrexate/cytarabine, high dose intravenous methotrexate, corticosteroids |
a
in addition to treatment exposures, all models were adjusted for the following covariates: age at evaluation, age at diagnosis, sex, race/ethnicity, body mass index (BMI), and physical inactivity
b
BMI removed as a covariate in the endocrine models because obesity is an outcome, grade 2 obesity excluded
c
treatment exposures classified as yes/no variables