. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: J Thromb Haemost. 2021 Apr 12;19(6):1483–1492. doi: 10.1111/jth.15299

TABLE 3.

Genotypic distribution of embryonic progeny derived from Tfpi^+/− × Tfpi^+/− crosses on the C57BL/6 J genetic background

Day of gestation	No. of embryos	Tfpi genotypes Obs (% of Total)
Day of gestation	No. of embryos	+/+		+/−		−/−
14.5	240	74	(31%)	132	(55%)	34	(14%)
15.5	69	23	(33%)	36	(52%)	10	(14%)
16.5	50	20	(40%)	23	(46%)	7	(14%)
Total	359	117	(33%)	191	(53%)	51	(14%)^a,b

Abbreviations: FDR, false discovery rate; Obs, Observed.

q-value = 1.2 × 10⁻⁶. FDR-adjusted probability from exact binomial test comparing Tfpi^−/− genotypes observed at E14.5 to E16.5 to the 25% Mendelian probability.

q value = 8.4 × 10⁻¹¹. FDR-adjusted probability from exact binomial test comparing Tfpi^−/− genotypes observed at E14.5 to E16.5 to the 5% probability reported in Huang et al.²⁶