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. Author manuscript; available in PMC: 2022 Jul 5.
Published in final edited form as: Eur J Med Chem. 2021 Apr 4;219:113425. doi: 10.1016/j.ejmech.2021.113425

Figure 2.

Figure 2.

Western blot profiling of degradation in RS4;11 leukemia cells. (A) Immunoblot of MDM2 and p53 following treatment of cells with DMSO or indicated compounds for 6 h; (B) Immunoblot of MDM2, p53 following incubation with 100 nM WB214 for indicated times; (C) Immunoblot of MDM2 and p53 following 12 h incubation with DMSO or the indicated concentrations of WB214; (D) Band intensity quantification of blot C calculated by Image J, and bar graph plotted and fitted by GraphPad Prism; E) Immunoblot of MDM2 and p53 following treatment with DMSO or indicated compounds for 6 h.