Figure 22.

Complementary Calca (red) and Pdyn (blue) patterns in the amygdala, hypothalamus and thalamus. (a) Calca projections densely innervate the lateral and capsular subdivisions of the CeA, with lighter labeling extending ventrally through the basomedial nucleus of the amygdala (BMA) and cortical nucleus of the amygdala (CoA). Medial to the amygdala, the zona incerta and lateral hypothalamic area (LHA) contained modest labeling along the edge of the IC. In the midline and intralaminar thalamus, dense labeling extends through the central median (CM), paracentral (PC), and centrolateral (CL) nuclei, with modest labeling in the xiphoid nucleus and paramedian labeling in the reuniens and rhomboid nuclei. There is also scattered labeling dorsally, in the mediodorsal, intermediodorsal, and paraventricular thalamic nuclei. (b) Pdyn projections avoid the amygdala and the majority of the thalamus, with the exception of dense, focal patch in the PVT, plus lighter labeling in the reuniens and xiphoid nuclei ventrally. In the hypothalamus, Pdyn projections form a continuously dense terminal field covering the LHA, dorsomedial hypothalamic (DMH), posterior hypothalamic (PH) and arcuate nuclei (Arc), encircling the ventromedial hypothalamic nucleus (VMH). (c) Combined labeling.