Table 1.
Clinical characteristics of 33 patients with COVID-19 related ARDS monitored using lung ultrasound score.
| Total (n=33) | Survivors (day 90) (n=21) | Non-survivors (day 90) (n=12) | P value | |
|---|---|---|---|---|
| Demographics | ||||
| Age (years) | 66 (56-69) | 66 (51-68) | 66 (57-80) | 0.095 |
| Women | 9 (27%) | 8 (38%) | 1 (8%) | 0.301 |
| BMI (kg/m2) | 28 (26-33) | 30 (27-34) | 27 (24-33) | 0.138 |
| SOFA | 8 (6-8) | 7 (6-8) | 8 (3-9) | 0.687 |
| SAPS II | 36 (32-44) | 36 (30-44) | 38 (33-48) | 0.542 |
| Charlson score | 2 (2-4) | 2 (1-3) | 4 (2-5) | 0.013 |
| ICU length of stay (days) | 22 (13-35) | 22 (15-40) | 23.5 (10-29) | 0.427 |
| At ARDS diagnosis | ||||
| Duration of symptoms (days) | 8 (6-10) | 9 (6-11) | 7.5 (7-9) | 0.427 |
| PEEP (cmH2O) | 14 (10-15) | 14 (10-15) | 14 (10-14) | 0.605 |
| Compliance (ml/cmH2O) | 35 (29-44) | 35 (29-48) | 33 (31-41) | 0.175 |
| PaO2/FiO2 ratio | 150 (88-177) | 150 (81-184) | 149 (92-166) | 0.646 |
| ARDS severity | ||||
| Mild | 3 (9%) | 3 (14%) | 0 (0%) | 0.562 |
| Moderate | 17 (52%) | 10 (48%) | 7 (58%) | |
| Severe | 13 (39%) | 9 (43%) | 4 (33%) | |
| CT scan grading (n=28) | ||||
| <25% | 8 (29%) | 7 (44%) | 1 (8%) | 0.217 |
| 25-50% | 11 (39%) | 5 (31%) | 6 (50%) | |
| 50-75% | 6 (21%) | 3 (19%) | 3 (25%) | |
| >75% | 3 (21%) | 1 (6%) | 2 (17%) | |
| Bacterial superinfection | 10 (30%) | 4 (19%) | 6 (50%) | 0.008 |
| Treatments | ||||
| Vasopressors | 32 (97%) | 21 (100%) | 11 (92%) | 0.443 |
| Renal replacement therapy | 11 (33%) | 4 (19%) | 7 (58%) | 0.021 |
| ECMO | 1 (3%) | 0 (0%) | 1 (8%) | 0.179 |
| Hydroxychloroquine | 25 (76%) | 14 (67%) | 11 (92%) | 0.014 |
| Corticosteroids | 13 (39%) | 11 (52%) | 2 (16%) | 0.201 |
| Complications | ||||
| Ventilator-associated pneumonia | 21 (63%) | 17 (81%) | 4 (33%) | 0.092 |
| Pulmonary embolism | 7 (21%) | 4 (19%) | 3 (25%) | 0.687 |
| Pneumothorax | 5 (15%) | 4 (19%) | 1 (8%) | 0.409 |
| LUS score | ||||
| Initial | 21 (19-24) | 22 (19-25) | 20 (19-21) | 0.210 |
| Maximum | 26 (25-27) | 26 (25-27) | 26 (24-29) | 0.696 |
| Minimum | 15 (14-19) | 15 (13-17) | 18 (14-21) | 0.078 |
| End of stay (discharge or death) | 23 (19-24) | 19 (17-23) | 25 (24-29) | <0.001 |
ARDS: acute respiratory distress syndrome; BMI: body mass index; CT: computerized tomography; ECMO: extracorporeal membrane oxygenation; ICU: intensive care unit; LUS: lung ultrasound score; PEEP: positive end expiratory pressure; SAPS II: simplified acute physiology score II; SOFA: sequential organ failure assessment.
Continuous variables are expressed as median (interquartile range)