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. 2021 May 31;39(4):487–503. doi: 10.1016/j.det.2021.05.006
Cutaneous Manifestation Subtype, if Applicable Morphology Additional Clinical Findings
Alopecia Androgenetic alopecia Hair loss from the anterior hairline moving posteriorly or thinning at the vertex scalp Associated with worse clinical outcomes in some studies148,149
Telogen effluvium Diffuse hair shedding 2–3 mo after a stressor150,151
Gianotti-Crosti-like rash Pruritic erythematous papules and vesicles on elbows, anterior thighs, and bilateral popliteal fossa coalescing into plaques.152 Rash started 18 d after onset of symptoms, 13 d after +COVID test, and 3 d after resolution of all respiratory and systemic symptoms.
SDRIFE-like Erythematous rash on bilateral axillae and antecubital fossae, which subsequently extended to trunk and inner thighs153,154
Grover-disease-like Red papules and papulovesicles distributed on the trunk155 Note: some evidence suggests clinical overlap with vesicular, or “varicella-like” eruptions
Erythema elevatum diutinum-like Firm symmetric smooth nodules on extensor surfaces, particularly joints156
Reactive infectious mucocutaneous eruption (formerly known as Mycoplasma-induced rash and mucositis) Shallow erosions of the vermilion lips, hard palate, periurethral glans penis.157 Reported patient with +COVID PCR 1 wk before rash onset, and again positive at rash onset. Mycoplasma PCR negative, IgM negative, IgG positive (consistent with past exposure).
Enanthems (eruptions of the mucous membranes) 83% (5 patients) with petechial enanthem ± macular enanthem158 Recorded from a group of 21 patients with COVID-19 and skin rash ranging from papulovesicular, purpuric periflexural, and erythema multiforme-like.
Oral lesions Aphthous-like, ulcerations, and macules, tongue depapillation, angular cheilitis, ulcers, blisters, white plaques, dark pigmentations.159 Etiology postulated to be multifactorial. Hypotheses include direct action of SARS-CoV-2 on oral mucosal cells, coinfection, immunity impairment, or adverse drug reactions160
Acute genital ulcers (Lipschütz ulcers) Necrotic ulcers with raised, sharply demarcated borders of the labia minora with no evidence of “kissing lesions.”161 Single oral aphtha was also observed, with no cutaneous involvement
Transient rash in newborns Transient “rash” (morphology not described) in babies born to mothers with COVID-19.162 Mottling noted in a neonate with sepsis and +COVID-19.163

Abbreviation: SDRIFE, symmetric drug-related intertriginous and flexural exanthema.