Table 2.
Kawasaki disease compared with multisystemic inflammatory syndrome in children
| Kawasaki Disease | Multisystem Inflammatory Syndrome in Children44 | |
|---|---|---|
| Demographics | ||
| Age | Younger children (90% of cases under age 5)110 | Mean age 9 years old |
| Geography | More common in Asia (Japan, South Korea, and Taiwan)111 | Majority of reports from the US and Europe |
| Race/ethnicity | Most common in Asian and Pacific Islanders112 | >65% of cases in Hispanic/Latino or non-Hispanic black children |
| Gender | Male predominance110 | Slight male predominance |
| Clinical signs | ||
| Fever | Unexplained fever lasting ≥5 d must be present112 | Fever lasting >24 h must be present |
| Conjunctivitis | 4 of 5 are part of diagnostic criteria (or 3 of 5 for incomplete KD)112 | <50% meet criteria for KD |
| Oral mucosal change | ||
| Distal extremity changes | ||
| Skin rash | ||
| Cervical lymphadenopathy | ||
| Gastrointestinal involvement | Present in 61%113 | Present in 87% |
| Respiratory involvement | Slightly less common Present in 35%113 |
Slightly more common Present in 41% |
| Cardiovascular shock | Less common Present in <10%114 |
More common Present in 66% |