Fig. 5.
Induction of efficient protection against SARS-CoV-2 in mice by SW0123. C57BL/6 mice received either an one-dose (OD) vaccination with 3 or 30 μg SW0123 in week 0, or two-dose (TD) vaccinations with the same dosage in weeks 0 and 3. BALB/c mice were immunized twice with 3 or 30 μg SW0123 in weeks 0 and 3. Mice in the mock group were administrated with empty vector as control. Mice (n = 6 each group) were transduced with rAdV5-expressing hACE2 13 weeks after first dosing, and were challenged intranasally with 5 × 105 TCID50 of SARS-CoV-2 (Wuhan/IVDC-HB-01/2019) 5 days of post-transduction. Lung tissues were harvested 4 days of post-challenge. a, c Viral titer levels in the lungs. Right lungs were homogenized and determined for viral titers. b, d Histology of lung sections. Left lungs were sectioned for hematoxylin and eosin (H&E) staining. Two-tailed Mann–Whitney test was used for statistical analysis. ***p < 0.001; ****p < 0.0001